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. 2013 Nov;151(2):728-737.
doi: 10.1016/j.jad.2013.07.036. Epub 2013 Aug 16.

Dynamic indices of methamphetamine dependence and HIV infection predict fluctuations in affective distress: a five-year longitudinal analysis

Jessica L Montoya  1 , Anya Umlauf  2 , Ian Abramson  3 , Jayraan Badiee  2 , Steven Paul Woods  2 , J Hampton Atkinson  4 , Igor Grant  2 , David J Moore  5 ; TMARC Group
Affiliations

Dynamic indices of methamphetamine dependence and HIV infection predict fluctuations in affective distress: a five-year longitudinal analysis

Jessica L Montoya et al. J Affect Disord. 2013 Nov.

Abstract

Background: Methamphetamine (METH) use and human immunodeficiency virus (HIV) infection are highly comorbid, and both are associated with increased prevalence of affective distress. Delineating the trajectory of affective distress in the context of METH dependence and HIV infection is important given the implications for everyday functional impairment, adverse health behaviors, and increased risk for adverse health outcomes.

Methods: We conducted a five-year longitudinal investigation involving 133 METH-dependent (74 HIV seropositive) and 163 non-METH-dependent (90 HIV seropositive) persons to examine both long-standing patterns and transient changes in affective distress. Mixed-effect regression models with random subject-specific slopes and intercepts evaluated the effect of METH dependence, HIV serostatus, and related variables on affective distress, as measured by the Profile of Mood States.

Results: Transient changes in affective distress were found to be greater among those with a diagnosis of current MDD, briefer durations of abstinence from METH, and higher quantity of METH consumed. Weak associations were observed among static (time-independent predictors) covariates and long-standing patterns in affective distress.

Limitations: Study lacked data pertaining to the participants' involvement in METH treatment and relied on respondent-driven sampling.

Conclusions: Our longitudinal investigation of the trajectory of affective distress indicated that specific and dynamic indices of current METH use were associated with greater transient changes in mood. In the evaluation and treatment of affective distress, recency and quantity of current METH use are important to consider given their association with heightened affective distress and mood instability over time.

Keywords: Affective distress; HIV; Longitudinal; Methamphetamine dependence.

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Conflict of interest statement

Conflict of Interest

The authors have no actual or potential conflict of interest, including any financial, personal or other relationships with other people or organizations within three years of beginning the work submitted that could inappropriately influence, or be perceived to influence, their work.

Figures

Figure 1
Figure 1
Mean POMS Total Mood Disturbance Scores by Visit for Each Group. The figure represents the trajectory of affective distress across the first five study visits (individual group cells contained n>15 at each visit depicted in the figure).
See this image and copyright information in PMC

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