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Case Reports
. 2014 Jan;21(1):180-3.
doi: 10.1016/j.jocn.2013.02.036. Epub 2013 Sep 5.

Primary large B-cell lymphoma of the fourth ventricle

Chih-Hsiang Liao  1 , Shih-Chieh Lin  2 , Sheng-Che Hung  3 , Sanford P C Hsu  4 , Donald Ming-Tak Ho  2 , Yang-Hsin Shih  5
Affiliations
Case Reports

Primary large B-cell lymphoma of the fourth ventricle

Chih-Hsiang Liao et al. J Clin Neurosci. 2014 Jan.

Abstract

We present a patient with an isolated primary central nervous system lymphoma (PCNSL) of the fourth ventricle. A 77-year-old man had a 1 week history of intermittent vertigo, nausea, vomiting, and progressively unsteady gait. CT scans of the brain showed a fourth ventricle tumor. MRI revealed a 2.5 cm dumbbell-shaped avidly-enhancing tumor in the fourth ventricle. Metastasis or high-grade glioma was suspected. The neuropathological findings were compatible with a diffuse large B-cell lymphoma. A slit lamp examination, bone marrow biopsy, and imaging studies for extracranial lesions were unremarkable. We suggest that PCNSL be listed in the differential diagnosis of fourth ventricle tumors with well-circumscribed margins and homogenous contrast enhancement.

Keywords: Central nervous system; Diffuse large-cell lymphoma; Fourth ventricle tumor; Immunocompetence; Non-Hodgkin’s lymphoma.

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