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. 2013 Nov;150(2-3):476-83.
doi: 10.1016/j.schres.2013.08.014. Epub 2013 Sep 6.

Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder

J Tilak Ratnanather  1 , Clare B Poynton, Dominic V Pisano, Britni Crocker, Elizabeth Postell, Shannon Cebron, Elvan Ceyhan, Nancy A Honeycutt, Pamela B Mahon, Patrick E Barta
Affiliations

Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder

J Tilak Ratnanather et al. Schizophr Res. 2013 Nov.

Abstract

Structural abnormalities in temporal lobe, including the superior temporal gyrus (STG) and planum temporale (PT), have been reported in schizophrenia (SCZ) and bipolar disorder (BPD) patients. While most MRI studies have suggested gray matter volume and surface area reduction in temporal lobe regions, few have explored changes in laminar thickness in PT and STG in SCZ and BPD. ROI subvolumes of the STG from 94 subjects were used to yield gray matter volume, gray/white surface area and laminar thickness for STG and PT cortical regions. Morphometric analysis suggests that there may be gender and laterality effects on the size and shape of the PT in BPD (n=36) and SCZ (n=31) with reduced laterality in PT in subjects with SCZ but not in BPD. In addition, PT surface area was seen to be larger in males, and asymmetry in PT surface area was larger in BPD. Subjects with SCZ had reduced thickness and smaller asymmetry in PT volume. Thus, the PT probably plays a more sensitive role than the STG in structural abnormalities seen in SCZ.

Keywords: Bipolar disorder; Laminar thickness; Laterality; Planum temporale; Schizophrenia; Superior temporal gyrus.

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Figures

Figure 1
Figure 1
Four delineated STG cortical surfaces. The colormap represents the distance of each vertex from the manually segmented STG surface. In general, vertices further than 2mm away from the manually segmented surface were located along the LF. Anterior and posterior locations are marked respectively by A and P in red.
Figure 2
Figure 2
STG volume in mm3 (top), surface area in mm3 (middle) and thickness in mm (bottom). Male and female gender is respectively indicated by circle and triangle while left and right side is respectively indicated by blue and red color. Means are indicated by thick lines.
Figure 3
Figure 3
PT volume in mm3 (top), surface area in mm3 (middle) and thickness in mm (bottom). Male and female gender is respectively indicated by circle and triangle while left and right side is respectively indicated by blue and red color. Means are indicated by thick lines.
See this image and copyright information in PMC

References

    1. Annett M. A classification of hand preference by association analysis. British journal of psychology. 1970;61(3):303–321. - PubMed
    1. Barta PE, Pearlson GD, Brill LB, 2nd, Royall R, McGilchrist IK, Pulver AE, Powers RE, Casanova MF, Tien AY, Frangou S, Petty RG. Planum temporale asymmetry reversal in schizophrenia: replication and relationship to gray matter abnormalities. The American journal of psychiatry. 1997;154(5):661–667. - PubMed
    1. Beasley CL, Chana G, Honavar M, Landau S, Everall IP, Cotter D. Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders. Schizophrenia research. 2005;73(1):69–78. - PubMed
    1. Brown GG, Lee JS, Strigo IA, Caligiuri MP, Meloy MJ, Lohr J. Voxel- based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study. Psychiatry research. 2011;194(2):149–156. - PMC - PubMed
    1. Calabrese DR, Wang L, Harms MP, Ratnanather JT, Barch DM, Cloninger CR, Thompson PA, Miller MI, Csernansky JG. Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings. Schizophrenia research. 2008;104(1-3):61–70. - PMC - PubMed

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