doi: 10.1007/BF00501817.
Inhibition of striatal dopamine synthesis in rats injected chronically with neuroleptics in their early life
- PMID: 240129
- DOI: 10.1007/BF00501817
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Inhibition of striatal dopamine synthesis in rats injected chronically with neuroleptics in their early life
Naunyn Schmiedebergs Arch Pharmacol.
1975.
Abstract
3H-dopamine synthesis from L-3,5-3H-tyrosine was reduced in striatal slices of 40 days old rats treated during their early life with neuroleptics. Animals were first injected intra-utero with thioproperazine (5 mg/kg) or with the palmitic ester of pipotiazine (32 mg/kg); the thioproperazine-treated rats were then injected every day from day 1 to day 37; the animals injected with the long acting neuroleptic were injected once more with the drug on day 15 after birth.
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