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Comment
. 2013 Sep;19(9):1092-4.
doi: 10.1038/nm.3333.

IL-17 mediates resistance to anti-VEGF therapy

Eleni Maniati  1 , Thorsten Hagemann
Affiliations
Comment

IL-17 mediates resistance to anti-VEGF therapy

Eleni Maniati et al. Nat Med. 2013 Sep.

Abstract

Interleukin-17 (IL-17) released in the tumor microenvironment in response to drugs blocking vascular endothelial growth factor (VEGF) triggers stromal-derived inflammatory and VEGF-independent angiogenic programs that induce the drug refractoriness found in cancers resistant to anti-angiogenic therapy.

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References

    1. Cancer Cell. 2005 Sep;8(3):211-26 - PubMed
    1. Cold Spring Harb Perspect Med. 2012 Dec 01;2(12):a006593 - PubMed
    1. J Leukoc Biol. 1994 Oct;56(4):423-35 - PubMed
    1. Nat Biotechnol. 2007 Aug;25(8):911-20 - PubMed
    1. Cancer Cell. 2013 Mar 18;23(3):277-86 - PubMed

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