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Comment
. 2013 Sep;19(9):1094-5.
doi: 10.1038/nm.3316.

Proliferating macrophages prevail in atherosclerosis

Gwendalyn J Randolph  1
Affiliations
Comment

Proliferating macrophages prevail in atherosclerosis

Gwendalyn J Randolph. Nat Med. 2013 Sep.

Abstract

Macrophages accumulate in atherosclerotic lesions during the inflammation that is part of atherosclerosis development and progression. A new study in mice indicates that the accumulation of macrophages in atherosclerotic plaques depends on local macrophage proliferation rather than the recruitment of circulating monocytes.

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Comment on

  • Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
    Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Robbins CS, et al. Nat Med. 2013 Sep;19(9):1166-72. doi: 10.1038/nm.3258. Epub 2013 Aug 11. Nat Med. 2013. PMID: 23933982 Free PMC article.

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