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Editorial
. 2013 Oct;20(10):1285-6.
doi: 10.1038/cdd.2013.95.

Reprogramming and genome integrity: role of non-homologous end joining

P Salomoni
Editorial

Reprogramming and genome integrity: role of non-homologous end joining

P Salomoni. Cell Death Differ. 2013 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Role of NHEJ in human-induced pluripotent stem cells (iPSCs). Tansduction of somatic cells with reprogramming factors is likely inducing DNA damage in addition to epigenetic/transcriptional reprogramming. In this context, NHEJ limits DNA damage, thus increasing reprogramming efficiency (left panel). In established IPSCs, NHEJ mediates repair of both endogenous and exogenous DNA damage, thus sustaining haematopoietic differentiation (right panel). Furthermore, NHEJ-mediated DNA repair suppressesinduction of a p53/ROCK non-canonical cell death pathway
See this image and copyright information in PMC

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References

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