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Editorial
. 2013 Oct;20(10):1287-8.
doi: 10.1038/cdd.2013.100.

Hippo signaling: to die or not to die

R I Aqeilan
Editorial

Hippo signaling: to die or not to die

R I Aqeilan. Cell Death Differ. 2013 Oct.
No abstract available

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Figures

Figure 1
Figure 1
In late response to DNA damage, c-Abl is activated leading to phosphorylation and activation of p73 (p73Y99-p), , and YAP (YAPY357-p) resulting in cell apoptosis. Reuven et al. demonstrate that upon exposure of dense cells to ionizing radiation, activated LATS2 phosphorylates c-Abl, hence inhibiting its kinase function and resulting in reduced p73Y99-p and YAPY357-p-mediated apoptosis leading to cytoprotection. According to this model, LATS2-mediated phosphorylation of YAP at S127 sequesters YAP in the cytoplasm, thus YAP could not function as co-activator of p73 to enhance apoptosis, thereby contributing also to cytoprotection
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References

    1. Reuven N, et al. Cell Death Differ 2013. e-pub ahead of print 12 July 2013; doi:10.1038/cdd.2013.83 - DOI
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    1. Zhao B, Tumaneng K, Guan KL. Nat Cell Biol. 2011. pp. 877–883. - PMC - PubMed
    1. Jackson SP, Bartek J. Nature. 2009. pp. 1071–1078. - PMC - PubMed

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