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. 2013 Oct 25;52(44):11573-6.
doi: 10.1002/anie.201304456. Epub 2013 Sep 6.

Rhodium-catalyzed oxidative annulation of sulfoximines and alkynes as an approach to 1,2-benzothiazines

Wanrong Dong  1 , Long Wang, Kanniyappan Parthasarathy, Fangfang Pan, Carsten Bolm
Affiliations

Rhodium-catalyzed oxidative annulation of sulfoximines and alkynes as an approach to 1,2-benzothiazines

Wanrong Dong et al. Angew Chem Int Ed Engl. .

Abstract

Revitalization by oxygen: A rhodium(III)-catalyzed oxidative CH/NH activation/annulation sequence provided access to a variety of substituted 1,2-benzothiazine derivatives from readily available NH-sulfoximines and alkynes (see scheme; Cp*=C5 Me5 ). The oxidation system consisted of molecular oxygen in combination with a catalytic amount of Fe(OAc)2 .

Keywords: 1,2-benzothiazines; CH activation; alkynes; annulation; sulfoximines.

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