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Controlled Clinical Trial
. 2013 Jul-Aug;45(4):391-4.
doi: 10.4103/0253-7613.115017.

Evaluation of anti-inflammatory effect of statins in chronic periodontitis

Snophia Suresh  1 , Satya Narayana, P Jayakumar, Uma Sudhakar, V Pramod
Affiliations
Controlled Clinical Trial

Evaluation of anti-inflammatory effect of statins in chronic periodontitis

Snophia Suresh et al. Indian J Pharmacol. 2013 Jul-Aug.

Abstract

Objectives: Statins are the group of lipid-lowering drugs commonly used to control cardiovascular and cerebrovascular diseases. Statins have potential anti-inflammatory effect by blocking the intermediate metabolites of the mevalonate pathway. The objective of this study was to evaluate the anti-inflammatory effect of statin medication in chronic periodontitis patients.

Materials and methods: Thirty patients of age group between 40 and 60 years were selected from the outpatient pool of Department of Periodontics, Thaimoogambigai Dental College and Hospital, Chennai. Thirty patients selected were grouped into two groups, Group-I consists of patients with generalized chronic periodontitis and on statin medication and Group-II consists of patients with generalized chronic periodontitis. Clinical parameters were recorded and gingival crevicular fluid (GCF) samples were analyzed for interleukin (IL)-1β using commercially available enzyme-linked immunosorbent assay.

Results: The mean GCF IL-1β levels in generalized chronic periodontitis patients who are on statin medication (Group-I) were lower than the generalized chronic periodontitis patients without statin medication (Group-II).

Conclusion: Reduction of GCF IL-1β levels in statin users indicate that statins have anti-inflammatory effect on periodontal disease.

Keywords: Chronic periodontitis; gingival crevicular fluid; interleukin-1β; statins.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Micropipette for collecting GCF
Figure 2
Figure 2
Microtitre plates
Figure 3
Figure 3
ELISA reader
Figure 4
Figure 4
Mean GCF IL-1b levels in Groups-I and II
See this image and copyright information in PMC

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