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Case Reports
. 2013 Jul-Aug;45(4):405-7.
doi: 10.4103/0253-7613.114998.

A case of thrombocytopenia caused by rifampicin and pyrazinamide

Rekha Bansal  1 , Parveen K Sharma, Aradhna Sharma
Affiliations
Case Reports

A case of thrombocytopenia caused by rifampicin and pyrazinamide

Rekha Bansal et al. Indian J Pharmacol. 2013 Jul-Aug.

Abstract

A 32-year-old male patient was diagnosed as having pulmonary tuberculosis and put on category II antitubercular regime since he had a history of antituberculosis treatment 10 years ago. Within 3 weeks, patient presented with ulcers in mouth, and blood picture confirmed thrombocytopenia. Rifampicin-induced thrombocytopenia was suspected and antitubercular treatment stopped. Patient improved and was re-exposed to the drugs one by one. After re-exposure with pyrazinamide, the platelet count decreased drastically and oral mucosal ecchymoses reappeared, while with rifampicin, thrombocytopenia was accompanied with petechiae on legs and forearms. Isoniazid, ethambutol, and streptomycin were continued.

Keywords: Antituberculosis treatment; ecchymoses; petechiae; thrombocytopenia.

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Conflict of interest statement

Conflict of Interest: Nil

Figures

Figure 1
Figure 1
Ecchymoses caused by pyrazinamide
Figure 2
Figure 2
Petechiae caused by rifampicin
See this image and copyright information in PMC

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