Eyelid angiosarcoma: a case report and review of the literature

Abstract

A 77-year-old woman presented with a 3-month history of a lesion on her left lower eyelid. External examination showed a tan-colored nodule with an overlying crust-covered ulcer on the left lower eyelid, nasally. The ulcer measured 12 mm × 7 mm. Complete surgical excision with a frozen section margin control was performed. Histopathological examination showed islands and sheets of spindle and epithelioid cells with little intervening stroma. The cells had copious amounts of either rounded or tapered eosinophilic cytoplasm with occasional intracytoplasmic lumina and large vesicular nuclei with prominent nucleoli. There was intense immunoreactivity for CD34, CD31, factor VIII, and Ki-67. The diagnosis was eyelid angiosarcoma. The patient refused any further therapy. At 1-year follow-up, there was no recurrence or development of metastasis. In conclusion, tan-colored eyelid nodules with overlying ulcer are usually a basal cell carcinoma; however, rarely it can be an eyelid angiosarcoma.

Keywords: Angiosarcoma; Eye; Eyelid; Soft Tissue Sarcoma; Tumor.

Figure 1

A tan-colored nodule with overlying crust-covered ulcer on the left lower eyelid nasally

Figure 2

Histopathological examination showed islands/sheets of spindle and epithelioid cells with little stroma. The cells had copious amounts of rounded or tapered eosinophilic cytoplasm and large vesicular nuclei with prominent nucleoli. (b) Immunoreactivity was intense for CD31 (c), CD34 (d), Factor VIII (e) and Ki-67. (f) (A. H and E, original magnification ×10, B. H and E, original magnification ×100, C. Immunohistochemistry for CD31, CD34, factor VIII and Ki-67 original magnification ×25)