Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 May;28(5):486-7.

Effect of piperine on pentobarbitone induced hypnosis in rats

A M Mujumdar  1 , J N Dhuley, V K Deshmukh, P H Raman, S L Thorat, S R Naik
Affiliations
  • PMID: 2401524

Effect of piperine on pentobarbitone induced hypnosis in rats

A M Mujumdar et al. Indian J Exp Biol. 1990 May.

Abstract

Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls. There was no alteration in barbital sodium sleeping time. It is possible that, piperine inhibits liver microsomal enzyme system and thereby potentiates the pentobarbitone sleeping time.

PubMed Disclaimer

LinkOut - more resources