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. 2014 Jan;13(1):69-73.
doi: 10.1016/j.jcf.2013.08.004. Epub 2013 Sep 7.

Cystic fibrosis and pregnancy in the modern era: a case control study

Monica Ahluwalia  1 , Jeffrey B Hoag  2 , Anas Hadeh  3 , Marianne Ferrin  1 , Denis Hadjiliadis  4
Affiliations
Free article

Cystic fibrosis and pregnancy in the modern era: a case control study

Monica Ahluwalia et al. J Cyst Fibros. 2014 Jan.
Free article

Abstract

Background: Increasingly, women with cystic fibrosis become pregnant. Outcomes of these women need further study particularly in the setting of improved survival in CF.

Methods: We performed a case-control study of pregnant CF women including 22 matched pairs with an average follow-up of 4.5 years. Nutritional outcomes, changes in lung function, and exacerbation rates were compared.

Results: Matched pairs were similar in age, sweat chloride, FEV1 and FVC % predicted, BMI, and diabetes status. Change in BMI, FEV1 and FVC % predicted at the end of pregnancy and at last follow-up were similar between groups. Moreover, rates of exacerbation before, during and after pregnancy were similar. On multivariable analysis pregnancy had no effect on change in lung function over the study period. Significant predictors of decline included higher pre-pregnancy lung function and pancreatic insufficiency.

Conclusions: Pregnancy does not lead to immediate or medium-term adverse effects for CF patients.

Keywords: Cystic fibrosis; Nutrition; Pregnancy.

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