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Review
. 2013 Oct;27(5):533-40.
doi: 10.1007/s40259-013-0070-1.

Pegylated liposomal doxorubicin: a guide to its use in various malignancies

Katherine A Lyseng-Williamson  1 , Sean T Duggan, Gillian M Keating
Affiliations
Review

Pegylated liposomal doxorubicin: a guide to its use in various malignancies

Katherine A Lyseng-Williamson et al. BioDrugs. 2013 Oct.

Abstract

Pegylated liposomal doxorubicin (Caelyx(®) [EU], Doxil(®) [USA]) represents an improved formulation of conventional doxorubicin, with reduced cardiotoxicity and an improved pharmacokinetic profile. As shown by evidence from clinical trials, intravenous pegylated liposomal doxorubicin is a useful option in the treatment of various malignancies, including metastatic breast cancer, ovarian cancer, multiple myeloma, and AIDS-related Kaposi sarcoma. It has a favourable safety profile relative to conventional doxorubicin and other available chemotherapy agents.

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