Genetics: RNA topoisomerase involved in neurodevelopmental disorders

Comment

Hemi Malkki. Nat Rev Neurol. 2013 Oct.

. 2013 Oct;9(10):542.

doi: 10.1038/nrneurol.2013.178. Epub 2013 Sep 10.

No abstract available

Comment on

Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation.
Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D 3rd, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MS, Gorospe M, Zou S, Wang W. Xu D, et al. Nat Neurosci. 2013 Sep;16(9):1238-47. doi: 10.1038/nn.3479. Epub 2013 Aug 4. Nat Neurosci. 2013. PMID: 23912945 Free PMC article.
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.
Stoll G, Pietiläinen OPH, Linder B, Suvisaari J, Brosi C, Hennah W, Leppä V, Torniainen M, Ripatti S, Ala-Mello S, Plöttner O, Rehnström K, Tuulio-Henriksson A, Varilo T, Tallila J, Kristiansson K, Isohanni M, Kaprio J, Eriksson JG, Raitakari OT, Lehtimäki T, Jarvelin MR, Salomaa V, Hurles M, Stefansson H, Peltonen L, Sullivan PF, Paunio T, Lönnqvist J, Daly MJ, Fischer U, Freimer NB, Palotie A. Stoll G, et al. Nat Neurosci. 2013 Sep;16(9):1228-1237. doi: 10.1038/nn.3484. Epub 2013 Aug 4. Nat Neurosci. 2013. PMID: 23912948 Free PMC article.