Antibacterial, antiurease, and antioxidant activities of some arylidene barbiturates
- PMID: 24018846
- PMCID: PMC3838783
- DOI: 10.1007/s12010-013-0486-6
Antibacterial, antiurease, and antioxidant activities of some arylidene barbiturates
Abstract
Some series of arylidene barbiturates and thiobarbiturates were evaluated for their antibacterial, antioxidant, and urease inhibition activities. The arylidene barbiturates and thiobarbiturates were tested for antimicrobial activity using the agar well diffusion technique against 13 bacteria. The synthesized compounds (1a-g) were screened for antiurease and antioxidant activities. The results showed that the synthesized compounds (1a-g) had effective antiurease, antioxidant, and antibacterial activities.
Similar articles
-
Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities.Eur J Med Chem. 2009 Oct;44(10):4235-43. doi: 10.1016/j.ejmech.2009.05.023. Epub 2009 May 28. Eur J Med Chem. 2009. PMID: 19552984
-
New barbiturates and thiobarbiturates as potential enzyme inhibitors.J Enzyme Inhib Med Chem. 2015 Feb;30(1):119-25. doi: 10.3109/14756366.2014.895717. Epub 2014 Mar 25. J Enzyme Inhib Med Chem. 2015. PMID: 24666295
-
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.Eur J Med Chem. 2018 Jan 1;143:829-842. doi: 10.1016/j.ejmech.2017.11.070. Epub 2017 Nov 27. Eur J Med Chem. 2018. PMID: 29223098
-
Synthesis, antibacterial, antielastase, antiurease and antioxidant activities of new methoxy substitued bis-1,2,4-triazole derivatives.J Enzyme Inhib Med Chem. 2013 Feb;28(1):72-7. doi: 10.3109/14756366.2011.631536. Epub 2011 Nov 15. J Enzyme Inhib Med Chem. 2013. PMID: 22085138
-
Antibacterial and antioxidant activities for natural and synthetic dual-active compounds.Eur J Med Chem. 2018 Oct 5;158:91-105. doi: 10.1016/j.ejmech.2018.09.009. Epub 2018 Sep 5. Eur J Med Chem. 2018. PMID: 30205261 Review.
Cited by
-
Antibacterial barbituric acid analogues inspired from natural 3-acyltetramic acids; synthesis, tautomerism and structure and physicochemical property-antibacterial activity relationships.Molecules. 2015 Feb 20;20(3):3582-627. doi: 10.3390/molecules20033582. Molecules. 2015. PMID: 25710842 Free PMC article.
-
A comprehensive In-silico analysis of the known and novel synthesized 5-substituted barbituric acid derivatives acting as CNS depressants.In Silico Pharmacol. 2025 Jun 9;13(2):82. doi: 10.1007/s40203-025-00376-8. eCollection 2025. In Silico Pharmacol. 2025. PMID: 40503561
-
Thiobarbiturate-Derived Compound MHY1025 Alleviates Renal Fibrosis by Modulating Oxidative Stress, Epithelial Inflammation, and Fibroblast Activation.Antioxidants (Basel). 2023 Oct 31;12(11):1947. doi: 10.3390/antiox12111947. Antioxidants (Basel). 2023. PMID: 38001800 Free PMC article.
-
An expedient metal-free cascade route to chromonyl diene scaffolds: thermodynamic vs. kinetic control.RSC Adv. 2022 Dec 7;12(54):34946-34950. doi: 10.1039/d2ra05704b. eCollection 2022 Dec 6. RSC Adv. 2022. PMID: 36540217 Free PMC article.
-
Antibacterial, Structural and Optical Characterization of Mechano-Chemically Prepared ZnO Nanoparticles.PLoS One. 2016 May 16;11(5):e0154704. doi: 10.1371/journal.pone.0154704. eCollection 2016. PLoS One. 2016. PMID: 27183165 Free PMC article.
References
-
- Khan KM, Ali M, Farooqui TA, Khan M, Taha M, Perveen S. Journal of the Chemical Society of Pakistan. 2009;31:823–828.
-
- Levina RY, Velichko FK. Russian Chemical Reviews. 1960;29:437–438. doi: 10.1070/RC1960v029n08ABEH001245. - DOI
-
- Sing P, Paul K. Indian Journal of Chemistry. 2006;45B:247–251.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases