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. 2013 Oct 4;19(41):13925-8.
doi: 10.1002/chem.201301988. Epub 2013 Sep 9.

Ruthenium(II)-catalyzed C-H alkenylations of phenols with removable directing groups

Wenbo Ma  1 , Lutz Ackermann
Affiliations

Ruthenium(II)-catalyzed C-H alkenylations of phenols with removable directing groups

Wenbo Ma et al. Chemistry. .

Abstract

Cationic ruthenium(II) complexes enabled oxidative alkenylations of phenols bearing easily cleavable directing groups. The optimized catalytic system allowed twofold CH bond activations with excellent chemo-, site-, and diastereoselectivities. The double CH functionalization process proceeded efficiently in an aerobic fashion under an atmosphere of ambient air. Detailed mechanistic studies were performed and provided strong support for an initial reversible CH bond activation by the formation of six-membered ruthenacycles as the key intermediates.

Keywords: CH activation; alkenylation; catalysis; cross-dehydrogenative coupling; reaction mechanisms; ruthenium.

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