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Case Reports
. 2013 Aug 17;5(2):225-31.
doi: 10.1159/000354767. eCollection 2013.

Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis

Hassan Riad  1 , Haya Al Mannai, Khalid Mansour, Khalifa Al Qaatri, Sharifa Al Dosari, Amina Al Obaidaly, Emad Sultan
Affiliations
Case Reports

Diphenylcyclopropenone-induced vitiligo in a patient with alopecia universalis

Hassan Riad et al. Case Rep Dermatol. .

Abstract

Alopecia areata and vitiligo are autoimmune diseases, both associated with multiple autoimmune comorbidities. Many studies show colocalization of these diseases at the same anatomical site. Here, we have a case where both disorders were reported to present in the same patient. Diphenylcyclopropenone (diphencyprone, DCP) is used in the treatment of alopecia areata and may induce vitiligo in some patients. We report on one case of vitiligo that was induced by DCP during therapy for alopecia universalis. Alopecia areata and vitiligo share many susceptibility genes. Follicular melanocyte destruction may represent the link between the two diseases.

Keywords: Alopecia; Diphenylcyclopropenone; Vitiligo.

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Figures

Fig. 1
Fig. 1
Photographs of the AU patient after the appearance of patches of vitiligo attributable to the application of DCP.
Fig. 2
Fig. 2
Photographs of the patient after therapy; notice the regrowth of hair and repigmentation of vitiligo in most of the affected areas.
See this image and copyright information in PMC

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