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Review
. 2013 May;10(3):287-95.

An insight into salivary markers in oral cancer

Ramnarayan Belur Krishna Prasad  1 , Akhilesh Sharma, Harsha Mysore Babu
Affiliations
Review

An insight into salivary markers in oral cancer

Ramnarayan Belur Krishna Prasad et al. Dent Res J (Isfahan). 2013 May.

Abstract

Salivary diagnostics has fascinated many researcheres and has been tested as a valuable tool in the diagnosis of many systemic conditions and for drug monitoring. Advances in the field of molecular biology, salivary genomics and proteomics have led to the discovery of new molecular markers for oral cancer diagnosis, therapeutics and prognosis. Oral cancer is a potentially fatal disease and the outcome of the treatment and prognosis largely depends on early diagnosis. Abnormal cellular products elucidated from malignant cells can be detected and measured in various body fluids including saliva and constitute tumor markers. This article discusses the various salivary tumor markers and their role in oral pre-cancer and cancer.

Keywords: DNA markers; RNA markers; oral cancer; protein markers; salivary markers; tumor markers.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Potentially malignant lesions (a) Leukoplakia and (b) Erosive Lichen planus
Figure 2
Figure 2
Various clinical presentations of oral cancer (a) Erythroleukoplakia (b) Ulcerative (c) Nodular/verruciod (d) Ulcero-proliferative
Figure 3
Figure 3
Photomicrograph showing (a) Severe dysplasia (b) Moderately differentiated OSCC
Figure 4
Figure 4
Mechanism that lead to the presence of molecular markers in saliva
See this image and copyright information in PMC

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