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. 2013 Mar;4(3-4):97-104.
doi: 10.1177/1947601912475079.

The Roles of SIRT1 in Cancer

Zhenghong Lin  1 , Deyu Fang
Affiliations

The Roles of SIRT1 in Cancer

Zhenghong Lin et al. Genes Cancer. 2013 Mar.

Abstract

The sirtuin family has emerged as important regulators of diverse physiological and pathological events, including life-span extension, neurodegeneration, age-related disorders, obesity, heart disease, inflammation, and cancer. In mammals, there are 7 members (SIRT1-SIRT7) in the sirtuin family, with the function of SIRT1 being extensively studied in the past decade. SIRT1 can deacetylate histones and a number of nonhistone substrates, which are involved in multiple signaling pathways. Numerous studies have suggested that SIRT1 could act as either a tumor suppressor or tumor promoter depending on its targets in specific signaling pathways or in specific cancers. This review highlights the major pathways regulated by SIRT1 involved in tumorigenesis.

Keywords: SIRT1; cancer; deacetylase.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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