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Review
. 2013 Sep;40(3):475-512.
doi: 10.1016/j.ogc.2013.05.009. Epub 2013 Jul 30.

Hereditary breast/ovarian cancer syndrome: a primer for obstetricians/gynecologists

Dana Meaney-Delman  1 , Cecelia A Bellcross
Affiliations
Review

Hereditary breast/ovarian cancer syndrome: a primer for obstetricians/gynecologists

Dana Meaney-Delman et al. Obstet Gynecol Clin North Am. 2013 Sep.

Abstract

An understanding of the diagnosis and clinical management of hereditary breast and ovarian cancer syndrome (HBOC) is essential for obstetricians/gynecologists. This article provides practical information regarding collecting a family history, cancer risk assessment and genetic testing, BRCA-associated cancer prognosis and treatment, screening recommendations, and prevention strategies. Through appropriate cancer risk assessment, women with BRCA1/2 mutations can be identified, and screening and prevention strategies can be used before a diagnosis of cancer occurs. Women's health providers with a strong working knowledge of HBOC are able to improve the quality of care for women and families impacted by BRCA1/2 mutations.

Keywords: BRCA1; BRCA2; Clinical management; Genetic testing; Hereditary breast cancer; Hereditary ovarian cancer.

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