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. 2013:2013:138248.
doi: 10.1155/2013/138248. Epub 2013 Aug 6.

A rare case report of amlodipine-induced gingival enlargement and review of its pathogenesis

Sanjeev Joshi  1 , Sucheta Bansal
Affiliations

A rare case report of amlodipine-induced gingival enlargement and review of its pathogenesis

Sanjeev Joshi et al. Case Rep Dent. 2013.

Abstract

Gingival enlargement is a common clinical feature of gingival and periodontal diseases. It is an unwanted side effect of certain systemic drugs given for nondental treatment. It is being reported with three main groups of drugs like calcium channel blockers (CCBs), immunosuppressants, and anticonvulsants. Among calcium channel blockers, nifedipine causes gingival hyperplasia in about 10% of patients, whereas the incidence of amlodipine-, a third generation calcium channel blocker, induced gingival hyperplasia is very limited. There are very few reports of amlodipine-induced gingival enlargement at a dose of 5 mg. We report a case of amlodipine-induced gingival enlargement in a 45-year-old hypertensive patient taking amlodipine at a dose of 5 mg.

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Figures

Figure 1
Figure 1
Showing generalized amlodipine-induced gingival enlargement.
Figure 2
Figure 2
Orthopantomography revealed generalized bone loss.
Figure 3
Figure 3
Showing response to therapy after 1.5 months.
See this image and copyright information in PMC

References

    1. Pradhan S, Mishra P. Gingival enlargement in antihypertensive medication. Journal of the Nepal Medical Association. 2009;48(174):149–152. - PubMed
    1. Rees TD, Levine RA. Systemic drugs as a risk factor periodontal disease initiation and progression. Compendium of Continuing Education in Dentistry. 1995;16(1):20–42. - PubMed
    1. Drug associated gingival enlargement. Journal of Periodontology. 2004;75(10):1424–1431. - PubMed
    1. Garzino-Demo P, Carbone M, Carrozzo M, Broccoletti R, Gandolfo S. An increase in gingival volume induced by drugs (phenytoin, cyclosporine and calcium antagonists). A review of the literature. Minerva Stomatologica. 1998;47(9):387–398. - PubMed
    1. Ellis JS, Seymour RA, Steele JG, Robertson P, Butler TJ, Thomason JM. Prevalence of gingival overgrowth induced by calcium channel blockers: a community-based study. Journal of Periodontology. 1999;70(1):63–67. - PubMed

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