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. 2013:2013:861232.
doi: 10.1155/2013/861232. Epub 2013 Aug 19.

Nonleukemic ureteral granulocytic sarcoma presenting with unilateral urinary obstruction and hematuria

Omer Acar  1 , Tarık Esen, Tülay Tecimer, Mustafa Cetiner, Onder Peker, Ahmet Musaoğlu
Affiliations

Nonleukemic ureteral granulocytic sarcoma presenting with unilateral urinary obstruction and hematuria

Omer Acar et al. Case Rep Urol. 2013.

Abstract

Granulocytic sarcoma is an extramedullary tumor which is composed of myeloblasts and immature myeloid cells. It usually occurs in association with acute myeloid leukemia and most commonly involves skin, soft tissue, lymph nodes, bone, and periosteum. We report a case of isolated ureteral granulocytic sarcoma without hematologic manifestations. Our patient presented with bloody urine and left-sided lumbar pain. Preoperative clinical and radiologic features raised the suspicion of an upper urinary tract transitional cell carcinoma, and he was scheduled for nephroureterectomy. However, perioperative pathologic feedback and the unusual endoscopic appearance of the tumor altered our surgical strategy towards segmental ureterectomy and ureteroneocystostomy. Eventual pathologic diagnosis was granulocytic sarcoma of the ureter. Postoperative workup failed to demonstrate any sign of an accompanying hematologic disorder. He started receiving the chemotherapy protocol of acute myeloblastic leukemia. To our knowledge, this is the first documented case of nonleukemic ureteral granulocytic sarcoma which came to attention due to urologic complaints.

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Figures

Figure 1
Figure 1
Coronal MR image demonstrating a solid mass located in the left distal ureter.
Figure 2
Figure 2
Coronal MR image demonstrating left-sided hydroureteronephrosis.
Figure 3
Figure 3
Macroscopic view of the excised ureteral segment.
Figure 4
Figure 4
Neoplastic blasts located under the ureteral epithelium.
Figure 5
Figure 5
Neoplastic cells staining positive for CD34.
Figure 6
Figure 6
Neoplastic cells showing myeloperoxidase reactivity.
See this image and copyright information in PMC

References

    1. Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC press; 2008.
    1. Eshghabadi M, Shojania AM, Carr I. Isolated granulocytic sarcoma: report of a case and review of the literature. Journal of Clinical Oncology. 1986;4(6):912–917. - PubMed
    1. Neiman RS, Barcos M, Berard C, et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. Cancer. 1981;48(6):1426–1437. - PubMed
    1. Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer. 1986;58(12):2697–2709. - PubMed
    1. Breccia M, Mandelli F, Petti MC, et al. Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. Leukemia Research. 2004;28(11):1165–1169. - PubMed

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