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. 2013 Aug 21:2013:186505.
doi: 10.1155/2013/186505. eCollection 2013.

Antimelanoma and antityrosinase from Alpinia galangal constituents

Chih-Yu Lo  1 , Po-Len Liu, Li-Ching Lin, Yen-Ting Chen, You-Cheng Hseu, Zhi-Hong Wen, Hui-Min Wang
Affiliations

Antimelanoma and antityrosinase from Alpinia galangal constituents

Chih-Yu Lo et al. ScientificWorldJournal. .

Abstract

Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry.

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Figures

Figure 1
Figure 1
The structure of 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC).
Figure 2
Figure 2
The effects of ginger extracts (BHPHTO and BDMC) on A2058 cell growths measured by MTT assay. The data represented the mean value ± SD of triplicate values for three independent experiments. Comparisons were subjected to Student's t-test. Significantly different at *P < 0.05.
Figure 3
Figure 3
The impact of BHPHTO and BDMC to B16-F10 melanoma cell viabilities. The data represented the mean value ± SD of triplicate values for three independent experiments. Comparisons were subjected to Student's t-test. Significantly different at *P < 0.05.
Figure 4
Figure 4
The tyrosinase activity of B16-F10 cells treated with various concentrations of BHPHTO and BDMC. The data represented the mean value ± SD of triplicate values for three independent experiments. Comparisons were subjected to Student's t-test. Significantly different at *P < 0.05.
Figure 5
Figure 5
The melanin content of B16-F10 cells treated with various concentrations of BHPHTO and BDMC. The data represented the mean value ± SD of triplicate values for three independent experiments. Comparisons were subjected to Student's t-test. Significantly different at *P < 0.05.
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