Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Jan;2(1):39-41.
doi: 10.4103/2249-4847.109248.

A Rare Case of Pyridoxine-dependent Seizures in Infancy

V S S Yerramilli Murty  1 , M S S Kishore, Manisha R Patel
Affiliations
Case Reports

A Rare Case of Pyridoxine-dependent Seizures in Infancy

V S S Yerramilli Murty et al. J Clin Neonatol. 2013 Jan.

Abstract

Pyridoxine-dependent seizures is a rare cause of recurrent seizures in neonatal period and resistant to most of the antiepileptic medications, but respond to administration of pyridoxine. We report a male infant who had neonatal seizures which were initially responsive to anticonvulsants and later became unresponsive and presented at 45 days of life with seizures. These seizures were not responding to any anticonvulsant but responded to pyridoxine. After discharge parents inadvertently stopped pyridoxine and the infant presented with seizures once again. These seizures were promptly controlled with readministration of pyridoxine confirming the diagnosis of pyridoxine-dependant seizures.

Keywords: Neonatal seizures; pyridoxine; pyridoxine-dependent seizures; resistant seizures.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Gospe SM., Jr Current perspectives on pyridoxine-dependent seizures. J Pediatr. 1998;132:919–23. - PubMed
    1. Kirksey A, Morré DM, Wasynczuk AZ. Neuronal development in vitamin B6 deficiency. Ann N Y Acad Sci. 1990;585:202–18. - PubMed
    1. Lin J, Lin K, Masruha MR, Vilanova LC. Pyridoxine-dependent epilepsy initially responsive to phenobarbital. Arq Neuropsiquiatr. 2007;65:1026–9. - PubMed
    1. Yoshii A, Takeoka M, Kelly PJ, Krishnamoorthy KS. Focal status epilepticus as atypical presentation of pyridoxine-dependent epilepsy. J Child Neurol. 2005;20:696–8. - PubMed
    1. Baxter P. Epidemiology of pyridoxine dependent and pyridoxine responsive seizures in the UK. Arch Dis Child. 1999;81:431–3. - PMC - PubMed

Publication types