Clinical practice guidelines for the treatment of invasive Aspergillus infections in adults in the Middle East region: Expert panel recommendations

Abstract

The incidence of invasive Aspergillus infections in the Middle East continues to rise with the increase in the number of immunocompromised patients, and carries significant morbidity and mortality. A panel of experts analysed the evidence from the most recent international guidelines and relevant published literature to reach consensus and develop clear clinical practice guidelines to aid diagnosis and treatment of invasive Aspergillus infections in the Middle East. Disease-specific recommendations were provided for the management of invasive aspergillosis. The expert panel acknowledged that these guidelines should be followed as closely as possible but used alongside clinical judgement.

Keywords: ABCD; ABLC; ABPA; AMB colloidal dispersion; AMB lipid complex; AMB-D; Aspergillosis; Aspergillus; CNPA; CNS; ECIL4; European Council on Infections in Leukaemia; GVHD; Guidelines; HEPA; IA; IDSA; Infectious Disease Society of America; L-AMB; LFAB; Middle East; Treatment; allergic bronchopulmonary aspergillosis; amphotericin B deoxycholate; central nervous system; chronic necrotising pulmonary aspergillosis; graft-versus-host disease; high-efficiency particulate air filtration; invasive aspergillosis; lipid formulations of amphotericin B; liposomal amphotericin B.