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Observational Study
. 2014 May;69(5):491-4.
doi: 10.1136/thoraxjnl-2013-203897. Epub 2013 Sep 12.

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)

David Couper  1 , Lisa M LaVange, MeiLan Han, R Graham Barr, Eugene Bleecker, Eric A Hoffman, Richard Kanner, Eric Kleerup, Fernando J Martinez, Prescott G Woodruff, Stephen Rennard; SPIROMICS Research Group
Collaborators, Affiliations
Observational Study

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)

David Couper et al. Thorax. 2014 May.

Abstract

Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinations, with quarterly telephone calls. Adjudication of exacerbations and mortality will be undertaken.

Keywords: COPD Exacerbations; COPD epidemiology; Emphysema; Imaging/CT MRI etc.

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References

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