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Comment
. 2013 Sep 13;341(6151):1175.
doi: 10.1126/science.1241854.

Response to Comment on "Influence of HLA-C expression level on HIV control"

Richard Apps  1 , Mary Carrington
Affiliations
Comment

Response to Comment on "Influence of HLA-C expression level on HIV control"

Richard Apps et al. Science. .

Abstract

Lo Monaco et al. propose that human leukocyte antigen E (HLA-E) and HLA-C expression levels both contribute to HIV control. The minimal, flat level of cell surface HLA-E detectable by staining with available HLA-E-specific antibodies questions a role for differential HLA-E expression in determining HIV control. Evidence remains far stronger that HLA-C expression levels as detected by the DT9 antibody specifically affect HIV control.

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Comment on

  • Influence of HLA-C expression level on HIV control.
    Apps R, Qi Y, Carlson JM, Chen H, Gao X, Thomas R, Yuki Y, Del Prete GQ, Goulder P, Brumme ZL, Brumme CJ, John M, Mallal S, Nelson G, Bosch R, Heckerman D, Stein JL, Soderberg KA, Moody MA, Denny TN, Zeng X, Fang J, Moffett A, Lifson JD, Goedert JJ, Buchbinder S, Kirk GD, Fellay J, McLaren P, Deeks SG, Pereyra F, Walker B, Michael NL, Weintrob A, Wolinsky S, Liao W, Carrington M. Apps R, et al. Science. 2013 Apr 5;340(6128):87-91. doi: 10.1126/science.1232685. Science. 2013. PMID: 23559252 Free PMC article.
  • Comment on "Influence of HLA-C expression level on HIV control".
    Lo Monaco E, Tremante E, Biswas P, Cranage MP, Zipeto D, Beretta A, Giacomini P. Lo Monaco E, et al. Science. 2013 Sep 13;341(6151):1175. doi: 10.1126/science.1241266. Science. 2013. PMID: 24031002

References

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    1. Apps R et al. , Science 340, 87–91 (2013). - PMC - PubMed