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. 2010 Sep;53(3):65-9.
Epub 2010 Sep 1.

Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report

Motoki Nakabayashi  1 , Kohei Shomori, Shuichi Kiya, Tatsushi Shiomi, Kanae Nosaka, Hisao Ito
Affiliations

Tubular-trabecular type Basal cell adenoma of the parotid gland: a patient report

Motoki Nakabayashi et al. Yonago Acta Med. 2010 Sep.

Abstract

Basal cell adenoma (BCA) is an uncommon benign salivary gland neoplasm that includes isomorphic basaloid cells. We report on a female patient with BCA that developed in the right parotid gland in her 50s. The present patient demonstrated a few tumor nests in the fibrous capsule, and her tumor was larger than usual. These facts made us suspect of malignancy. Histopathologically, the tumor was characterized by multiple duct-like structures and tubular-trabecular masses composed of small isomorphic cells with hyperchromatic, round nuclei and an eosinophilic cytoplasm. It was difficult to determine whether the ductal structures noted in the tumor capsule were invasive. By immunohistochemistry, tumor cells of the tubular nests were positive for cytokeratin 7 and that the outer cells of tubular nests were positive for alpha smooth muscle actin (αSMA) and calponin. Tumor cells were immuno-negative for S-100 protein and glial fibrillary acidic protein. The Ki-67 labeling scores of the cells were extremely low (< 1%). We could achieve an accurate diagnosis of BCA by immunohistochemistry with MIB-1 and other markers.

Keywords: basal cell adenoma; immunohistochemistry; parotid gland.

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Figures

Fig. 1.
Fig. 1.
Contrast-enhanced magnetic resonance scans showing homogeneous moderate enhancement of the mass (arrow). Capsule-like enhancement is seen. a: T1-weighted image. b: T2-weighted image.
Fig. 2.
Fig. 2.
Histopathology of the basal cell adenoma (hematoxylin and eosin stain). a: The tumor cells demonstrate a tubular structure. Bar = 50 μm. b: Trabecular tumor cells and tumor cell nest formation. Bar = 50 μm. c: Trabecular tumor cell nests are noted in the fibrous capsule of the tumor, mimicking infiltration. Bar = 100 μm.
Fig. 3.
Fig. 3.
Immunohistochemistry of the basal cell adenoma. a: The tumor cells show immunoreactivity for cytokeratin 7. Bar = 50 μm. b: Alpha smooth muscle actin immunoreactivity is noted in the outermost layer of the tubular type tumor cells. Bar = 50 μm.
See this image and copyright information in PMC

References

    1. Barnes L, Eveson JW, Reichart P, Sidransky D. World Health Organization classification of tumours. Pathology and genetics of head and neck tumours Lyon : International Agency for Research on Cancer Press; 2005. p. 261–262
    1. Dardick I, Daley TD, van Nostrand AW. Basal cell adenoma with myoepithelial cell-derived "stroma": a new major salivary gland tumor entity. Head Neck Surg 1986; 8: 257–267 - PubMed
    1. Ellis GL, Auclair PL.Tumor of the salivary glands. Atlas of tumor pathology. Washington DC: Armed Forces Institute of Pathology; 1996. p. 90 –94
    1. Evenson JW, Cawson RA. Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. J Oral Pathol 1985; 14: 500–509 - PubMed
    1. Gnepp DR. Diagnostic surgical pathology of the head and neck. London: W. B. Saunders; 2009. p. 351–365