Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Oct;132(4):746-8.
doi: 10.1093/oxfordjournals.aje.a115716.

Does nondifferential misclassification of exposure always bias a true effect toward the null value?

M Dosemeci  1 , S Wacholder, J H Lubin
Affiliations

Does nondifferential misclassification of exposure always bias a true effect toward the null value?

M Dosemeci et al. Am J Epidemiol. 1990 Oct.

Abstract

The authors present some examples to demonstrate that in certain nondifferential misclassification conditions with polychotomous exposure variables, estimates of odds ratios for categories at intermediate level of risk can be biased away from the null or can change direction. In addition, the authors present two examples to demonstrate that the slope of the dose-response trend for the true distributions can change direction, creating a false inverse trend, even if the misclassification is nondifferential.

PubMed Disclaimer

Comment in

LinkOut - more resources