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Review
. 2013 Sep 2:7:546.
doi: 10.3389/fnhum.2013.00546.

Hemispheric lateralization interrupted: material-specific memory deficits in temporal lobe epilepsy

Kim Celone Willment  1 , Alexandra Golby
Affiliations
Review

Hemispheric lateralization interrupted: material-specific memory deficits in temporal lobe epilepsy

Kim Celone Willment et al. Front Hum Neurosci. .

Abstract

The hemispheric lateralization of memory has largely been informed through the study of patients with temporal lobe epilepsy originating from medial temporal sources (mTLE). The material-specific model of memory relies on the basic framework that the left temporal lobe mediates verbal memories, while the right temporal lobe mediates non-verbal memories. Over the years, this model has been refined, and even challenged, as our understanding of the material-specific memory deficits in mTLE has been further elaborated in the neuropsychological and neuroimaging literature. The first goal of this mini-review is to highlight the major findings in the mTLE literature that have advanced and expanded our understanding of material-specific memory deficits in mTLE. Second, we will review how functional neuroimaging patterns of material-specific hemispheric lateralization in mTLE are being translated into the innovative clinical application of preoperative fMRI memory mapping.

Keywords: fMRI; hemispheric lateralization; material-specific; memory; temporal lobe epilepsy.

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