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Comparative Study
. 2013 Nov;163(3):400-3.
doi: 10.1111/bjh.12517. Epub 2013 Aug 16.

Impact of heart magnetic resonance imaging on chelation choices, compliance with treatment and risk of heart disease in patients with thalassaemia major

Raffaella Origa  1 , Fabrice Danjou, Stefano Cossa, Gildo Matta, Patrizio Bina, Carlo Dessì, Elisabetta Defraia, Maria L Foschini, Giovanbattista Leoni, Maddalena Morittu, Renzo Galanello
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Comparative Study

Impact of heart magnetic resonance imaging on chelation choices, compliance with treatment and risk of heart disease in patients with thalassaemia major

Raffaella Origa et al. Br J Haematol. 2013 Nov.

Abstract

This study aimed to verify the impact of heart magnetic resonance imaging on chelation choices and patient compliance in a single-institution cohort as well as its predictive value for heart failure and arrhythmias. Abnormal cardiac T2* values determined changes in treatment in most subjects. Heart T2* was confirmed to be highly predictive over 1 year for heart failure and arrhythmias. The choice of chelation regimens known to remove heart iron efficiently was not sufficient by itself to influence the risk. Compliance with treatment had a more remarkable role.

Keywords: arrhythmia; beta thalassaemia major; compliance; heart failure; heart magnetic resonance imaging.

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