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Review
. 2013 Oct;57(4):611-30.
doi: 10.1016/j.cden.2013.07.003. Epub 2013 Aug 15.

Mucous membrane pemphigoid

Hong-Hui Xu  1 , Victoria P Werth, Ernesta Parisi, Thomas P Sollecito
Affiliations
Review

Mucous membrane pemphigoid

Hong-Hui Xu et al. Dent Clin North Am. 2013 Oct.

Abstract

Mucous membrane pemphigoid (MMP) is chronic and frequently associated with exacerbations and remissions of clinical signs and symptoms. Clinicians should use pathologic and immunonologic techniques to help diagnose patients. Multidisciplinary collaboration is often necessary for the diagnosis and proper treatment of MMP. Systemic adjuvant immunosuppressive therapy is necessary for patients with progressive disease. In spite of the advances in available immunosuppressive medications and biologics, scarring is a significant complication in many cases. Surgical intervention is not curable; however, it may be necessary for restoring function and improving quality of life.

Keywords: Cicatricial pemphigoid; Mucous membrane; Ocular; Oral; Subepithelial autoimmune disease.

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Conflict of interest statement

Conflict of interest: The authors have nothing to disclose.

Figures

Fig. 1
Fig. 1
Components of the basement membrane zone.
Fig. 2
Fig. 2
Ulceration and the scarring on the buccal mucosa of a patient with MMP.
Fig. 3
Fig. 3
Intact blood-filled vesicle.
Fig. 4
Fig. 4
Symblepharon formation resulting from the scarring of the bulbar and palpebral conjunctiva
Fig. 5
Fig. 5
A resilient splint serving as an occlusive dressing over the attached gingiva.
Fig. 6
Fig. 6
Intralesional injection of steroid preparation.
Fig. 7
Fig. 7
Treatment algorithm for MMP. CR, complete response; NR, no response; PR, partial response.
See this image and copyright information in PMC

References

    1. Chan LS, Ahmed AR, Anhalt GJ, et al. The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. Arch Dermatol. 2002;138:370–9. - PubMed
    1. Schmidt E, Zillikens D. Pemphigoid diseases. Lancet. 2013;381:320–32. - PubMed
    1. Srikumaran D, Akpek EK. Mucous membrane pemphigoid: recent advances. Current opinion in ophthalmology. 2012;23:523–7. - PubMed
    1. Schmidt E, Skrobek C, Kromminga A, et al. Cicatricial pemphigoid: IgA and IgG autoantibodies target epitopes on both intra- and extracellular domains of bullous pemphigoid antigen 180. Br J Dermatol. 2001;145:778–83. - PubMed
    1. Bernard P, Prost C, Lecerf V, et al. Studies of cicatricial pemphigoid autoantibodies using direct immunoelectron microscopy and immunoblot analysis. J Invest Dermatol. 1990;94:630–5. - PubMed

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