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Comment
. 2013 Sep 12;154(6):1184-6.
doi: 10.1016/j.cell.2013.08.040.

Self-eating limits EGFR-dependent tumor growth

Valeria R Fantin  1 , Robert T Abraham
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Free article
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Self-eating limits EGFR-dependent tumor growth

Valeria R Fantin et al. Cell. .
Free article

Abstract

Autophagy is a cell-autonomous, catabolic process that plays context-dependent roles in tumor growth and progression. Wei et al. report that EGFR signaling promotes tumor growth through phosphorylation and functional inactivation of Beclin 1 and the consequent suppression of autophagy.

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