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Comment
. 2013 Sep 12;51(5):557-8.
doi: 10.1016/j.molcel.2013.08.033.

Opening the Chromatin by eRNAs

Ramin Shiekhattar  1
Affiliations
Comment

Opening the Chromatin by eRNAs

Ramin Shiekhattar. Mol Cell. .

Abstract

Enhancer RNAs (eRNAs) have emerged as an important component of transcriptional activation. In this issue, Mousavi et al. (2013) have uncovered a critical role for eRNAs in regulation of myogenic differentiation program through increasing chromatin accessibility at MyoD and MyoG loci.

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Figures

Figure 1
Figure 1. eRNAs Expressed from Core Enhancer Element Lead to Chromatin Opening and Transcription at MyoD Locus
eRNAs are expressed from the core enhancer element of the MyoD regulatory region following a differentiating stimuli. CE-expressed eRNAs function by recruiting chromatin remodeling factors to provide chromatin accessibility leading to increased RNA polymerase II occupancy.
See this image and copyright information in PMC

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References

    1. De Santa F, Barozzi I, Mietton F, Ghisletti S, Polletti S, Tusi BK, Muller H, Ragoussis J, Wei CL, Natoli G. PLoS Biol. 2010;8:e1000384. - PMC - PubMed
    1. Hah N, Murakami S, Nagari A, Danko CG, Kraus WL. Genome Res. 2013;23:1210–1223. - PMC - PubMed
    1. Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, et al. Nature. 2010;465:182–187. - PMC - PubMed
    1. Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, et al. Nature. 2013;498:511–515. - PMC - PubMed
    1. Li W, Notani D, Ma Q, Tanasa B, Nunez E, Chen AY, Merkurjev D, Zhang J, Ohgi K, Song X, et al. Nature. 2013;498:516–520. - PMC - PubMed