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Review
. 2013 Nov;34(11):540-7.
doi: 10.1016/j.it.2013.08.004. Epub 2013 Sep 12.

Innate immune cells in asthma

Julie Deckers  1 , Filipe Branco Madeira, Hamida Hammad
Affiliations
Review

Innate immune cells in asthma

Julie Deckers et al. Trends Immunol. 2013 Nov.

Abstract

Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity.

Keywords: Th2; asthma; innate cells; lung.

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