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. 1990 Jan;143(1):143-5.
doi: 10.1016/s0022-5347(17)39898-1.

Decreased immunologic responsiveness following intensified vaginal immunization against urinary tract infection

D T Uehling  1 , W J Hopkins, E Balish
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Decreased immunologic responsiveness following intensified vaginal immunization against urinary tract infection

D T Uehling et al. J Urol. 1990 Jan.

Abstract

In an attempt to further increase the protective effect of vaginal immunization against urinary tract infections in Cynomolgus monkeys, the immunogen of killed E. coli was given more times, in larger amounts, and with the adjuvant MDP. Instead of increasing the protective effect, no protective effect on induced cystitis was observed. In addition, rises in urinary and serum immunoglobulins previously observed after vaginal immunization and induced cystitis were lessened. These observations appear to correspond with the classical concepts of immunologic unresponsiveness.

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