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Editorial
. 2013 Nov 1;12(21):3345-6.
doi: 10.4161/cc.26401. Epub 2013 Sep 13.

Targeted cholesterol efflux

Longhou Fang  1 , Yury I Miller
Affiliations
Editorial

Targeted cholesterol efflux

Longhou Fang et al. Cell Cycle. .
No abstract available

Keywords: angiogenesis; apoA-I binding protein; cholesterol efflux; endothelial cell; lipid rafts; reverse cholesterol transport; zebrafish.

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Figures

None
Figure 1. AIBP-targeted cholesterol efflux from EC disrupts lipid rafts and inhibits angiogenesis. VEGFR2 signaling in response to VEGF requires the receptor dimerization, which occurs in the cholesterol-rich membrane microdomains, often designated as lipid rafts. As the name implies, AIBP binds apoA-I and HDL; it also binds EC in a saturable manner, which suggests a receptor-mediated binding, but the hypothetical AIBP receptor (AIBP-R) has not yet been identified. AIBP increases the overall HDL binding to EC and at the same time reduces the affinity of HDL binding, thereby creating conditions for accelerated cholesterol efflux. Enhanced removal of cholesterol from the EC plasma membrane disrupts lipid rafts, which, in turn, inhibits VEGFR2 signaling and VEGF-induced angiogenesis. HDL transports cholesterol removed from the cell (in free and esterified forms) to the liver.
See this image and copyright information in PMC

Comment on

  • Control of angiogenesis by AIBP-mediated cholesterol efflux.
    Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, Torres-Vázquez J, Li AC, Miller YI. Fang L, et al. Nature. 2013 Jun 6;498(7452):118-22. doi: 10.1038/nature12166. Epub 2013 May 29. Nature. 2013. PMID: 23719382 Free PMC article.

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