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Comment
. 2013 Nov;10(6):456-8.
doi: 10.1038/cmi.2013.38. Epub 2013 Sep 16.

CD52 as both a marker and an effector molecule of T cells with regulatory action: Identification of novel regulatory T cells

Buka Samten
Comment

CD52 as both a marker and an effector molecule of T cells with regulatory action: Identification of novel regulatory T cells

Buka Samten. Cell Mol Immunol. 2013 Nov.
No abstract available

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Figures

Figure 1
Figure 1
CD52hiCD4+ T cells inhibit CD52loCD4+ T-cell activation through the release of cell surface CD52. GPI-anchored, membrane-bound CD52 core molecules from CD52hiCD4+ T cells are released by phospholipase C cleavage. Free CD52 interacts with Siglec-10 on responder CD52loCD4+ T cells and inhibits the activation of the responder cells by blocking Lck and Zap70 phosphorylation. GPI, glycosylphosphatidylinositol; Siglec, sialic acid-binding immunoglobulin-like lectin.
See this image and copyright information in PMC

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