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. 2014 Mar 15;134(6):1436-44.
doi: 10.1002/ijc.28469. Epub 2013 Oct 5.

Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort

S Rinaldi  1 , C Biessy, M Hernandez, F Lesueur, I dos-Santos-Silva, M S Rice, M Lajous, R Lopez-Ridaura, G Torres-Mejía, I Romieu
Affiliations

Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort

S Rinaldi et al. Int J Cancer. .

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Int J Cancer. 2016 Sep 15;139(6):E10. doi: 10.1002/ijc.30112. Int J Cancer. 2016. PMID: 27392813 No abstract available.

Abstract

The insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide polymorphisms (SNPs) in genes of the IGF pathway have also been suggested to play a role in mammographic density. We conducted a cross-sectional study nested within the large Mexican ESMaestras cohort to investigate the relation between circulating levels of IGF-I, IGFBP-3, the IGF-I/IGFBP-3 ratio, five common SNPs in the IGF-1, IGFBP-3 and IGF-1R genes and mammographic density in 593 premenopausal Mexican women. Mean age at mammogram was 43.1 (standard deviation, SD = 3.7) years, and average body mass index (BMI) at recruitment was 28.5 kg/m(2). Mean percent mammographic density was 36.5% (SD: 17.1), with mean dense tissue area of 48.3 (SD: 33.3) cm(2) . Mean IGF-I and IGFBP-3 concentrations were 15.33 (SD: 5.52) nmol/l and 114.96 (SD: 21.34) nmol/l, respectively. No significant associations were seen between percent density and biomarker concentrations, but women with higher IGF-I and IGF-I/IGFBP-3 concentrations had lower absolute dense (p(trend) = 0.03 and 0.09, respectively) and nondense tissue areas (p(trend) < 0.001 for both parameters). However, these associations were null after adjustment by BMI. SNPs in specific genes were associated with circulating levels of growth factors, but not with mammographic density features. These results do not support the hypothesis of a strong association between circulating levels of growth hormones and mammographic density in Mexican premenopausal women.

Keywords: IGF; Mexican premenopausal women; genetic polymorphisms; mammographic density.

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Conflict of interest statement

Conflict of Interest: None disclosed

Figures

Fig 1
Fig 1
Adjusteda mean IGF-I circulating levels and mean percent breast density (with 95% confidence intervals) in 593 premenopausal Mexican women by deciles of BMI aAdjusted by age, batch (for IGF-I) and state
See this image and copyright information in PMC

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