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Review
. 2013 Dec;36(12):737-42.
doi: 10.1002/clc.22195. Epub 2013 Aug 27.

Methamphetamine-associated cardiomyopathy

Sekon Won  1 , Robert A Hong, Ralph V Shohet, Todd B Seto, Nisha I Parikh
Affiliations
Review

Methamphetamine-associated cardiomyopathy

Sekon Won et al. Clin Cardiol. 2013 Dec.

Abstract

Methamphetamine and related compounds are now the second most commonly used illicit substance worldwide, after cannabis. Reports of methamphetamine-associated cardiomyopathy (MAC) are increasing, but MAC has not been well reviewed. This analysis of MAC will provide an overview of the pharmacology of methamphetamine, historical perspective and epidemiology, a review of case and clinical studies, and a summary of the proposed mechanisms for MAC. Clinically, many questions remain, including the appropriate therapeutic interventions for MAC, the incidence and prevalence of cardiac pathology in methamphetamine users, risk factors for developing MAC, and prognosis of these patients. In conclusion, recognition of the significance of MAC among physicians and other medical caregivers is important given the growing use of methamphetamine and related stimulants worldwide.

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Figures

Figure 1
Figure 1
Chemical structures of methamphetamine and related compounds.11
Figure 2
Figure 2
Primary methamphetamine/amphetamine admission rates by state,1994–2004 (per 100 000 population age ≥12).19
See this image and copyright information in PMC

Comment in

References

    1. United Nations Office on Drugs and Crime . World Drug Report 2010 http://www.unodc.org/documents/wdr/WDR_2010/World_Drug_Report_2010_lo‐re....
    1. US Department of Health and Human Services, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality. Statistics for US community hospital stays, principal diagnosis based on CCS (Clinical Classifications Software), 2010. http://hcupnet.ahrq.gov/HCUPnet.jsp?Id=C4D88AA0629A6D0E&Form=DispTab&JS=....
    1. Diercks DB, Fonarow GC, Kirk JD, et al; ADHERE Scientific Advisory Committee and Investigators. Illicit stimulant use in a United States heart failure population presenting to the emergency department (from the Acute Decompensated Heart Failure National Registry Emergency Module). Am J Cardiol. 2008;102:1216–1219. - PubMed
    1. Schep LJ, Slaughter RJ, Beasley DM. The clinical toxicology of metamfetamine. Clin Toxicol (Phila). 2010;48:675–694. - PubMed
    1. Cho AK. Ice: a new dosage form of an old drug. Science. 1990;249:631–634. - PubMed

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