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Clinical Trial
. 1990 Jan;51(1):8-11.

What constitutes an adequate antidepressant trial for fluoxetine?

E Schweizer  1 , K Rickels, J D Amsterdam, I Fox, G Puzzuoli, C Weise
Affiliations
  • PMID: 2403998
Clinical Trial

What constitutes an adequate antidepressant trial for fluoxetine?

E Schweizer et al. J Clin Psychiatry. 1990 Jan.

Abstract

One hundred and eight patients with major depression were treated with fluoxetine 20 mg/day for 3 weeks. Patients who failed to respond to this open-label treatment were randomly assigned either to receive fluoxetine 60 mg/day for 5 weeks or to continue treatment with fluoxetine 20 mg/day for an additional 5 weeks. Both treatment groups demonstrated a statistically significant reduction in depressive symptoms, indicating that continued treatment with low-dose fluoxetine may be as effective as an increase in dose in achieving a favorable clinical outcome.

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