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. 2014 Jun;142(6):1138-45.
doi: 10.1017/S0950268813002215. Epub 2013 Sep 16.

Evolutionary history of Ebola virus

Y H Li  1 , S P Chen  2
Affiliations

Evolutionary history of Ebola virus

Y H Li et al. Epidemiol Infect. 2014 Jun.

Abstract

Since Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, we propose a hypothesis of the evolutionary history of Ebola virus which will be helpful to investigate the molecular evolution of these viruses.

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Figures

Fig. 1.
Fig. 1.
The phylogenetic relationship of Ebola virus (EBOV) isolates. The complete GP nucleotide sequences were analysed by the maximum-likelihood method using the TREE-PUZZLE program. Taxon names corresponded to ‘strain name + isolation place + isolation time’. Bootstrap values are shown on the key nodes of the trees. The trees were rooted by Marburg virus (AF005734).
Fig. 2.
Fig. 2.
Relative genetic diversities of Ebola virus (EBOV) and each species over time. (a) EBOV; (b) EBOV-Z; (c) EBOV-R; (d) EBOV-S. The box [in panel (a)] denotes the time span from 1948 to 1987 which was the confidence intervals covering EBOV-Z, EBOV-S, and EBOV-R.
See this image and copyright information in PMC

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