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. 1990 Jan 1;171(1):307-14.
doi: 10.1084/jem.171.1.307.

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection

C P Larsen  1 , P J Morris, J M Austyn
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Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection

C P Larsen et al. J Exp Med. .

Abstract

It has been a long-standing dogma that host sensitization against fully-vascularized organ allografts occurs peripherally within the graft itself. In this report we show that donor-derived MHC class II-positive (Ia+) DL migrate rapidly out of mouse cardiac allografts into the recipients' spleens where they home to the peripheral white pulp and associate predominantly with CD4+ T lymphocytes. This provides a novel route for central sensitization against fully vascularized allografts, and most likely represents a pathway by which immune responses are generated against antigens on blood-borne DL emigrating from peripheral tissues.

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