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. 2013 Sep 16;5(1):24.
doi: 10.1186/1866-1955-5-24.

Resting state EEG abnormalities in autism spectrum disorders

Jun Wang #  1 , Jamie Barstein #  1 , Lauren E Ethridge  1 , Matthew W Mosconi  1   2 , Yukari Takarae  1 , John A Sweeney  1   2   3
Affiliations

Resting state EEG abnormalities in autism spectrum disorders

Jun Wang et al. J Neurodev Disord. .

Abstract

Autism spectrum disorders (ASD) are a group of complex and heterogeneous developmental disorders involving multiple neural system dysfunctions. In an effort to understand neurophysiological substrates, identify etiopathophysiologically distinct subgroups of patients, and track outcomes of novel treatments with translational biomarkers, EEG (electroencephalography) studies offer a promising research strategy in ASD. Resting-state EEG studies of ASD suggest a U-shaped profile of electrophysiological power alterations, with excessive power in low-frequency and high-frequency bands, abnormal functional connectivity, and enhanced power in the left hemisphere of the brain. In this review, we provide a summary of recent findings, discuss limitations in available research that may contribute to inconsistencies in the literature, and offer suggestions for future research in this area for advancing the understanding of ASD.

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Figures

Figure 1
Figure 1
Illustration of the U-shaped profile of abnormal power pattern in autism spectrum disorders (ASD).
See this image and copyright information in PMC

References

    1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders-4th edition. 2000.
    1. Centers for Disease Control and Prevention. Prevalence of autism spectrum disorders--Autism and Developmental Disabilities Monitoring Network, 14 sites. 2012. - PubMed
    1. Muhle R, Trentacoste SV, Rapin I. The genetics of autism. Pediatrics. 2004;113:e472–e486. doi: 10.1542/peds.113.5.e472. - DOI - PubMed
    1. Ozonoff S, Young GS, Carter A, Messinger D, Yirmiya N, Zwaigenbaum L, Bryson S, Carver LJ, Constantino JN, Dobkins K. et al. Recurrence risk for autism spectrum disorders: a baby siblings research consortium study. Pediatrics. 2011;128:e488–e495. - PMC - PubMed
    1. Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet. 2008;9:341–355. doi: 10.1038/nrg2346. - DOI - PMC - PubMed