Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Dec;57(12):6344-7.
doi: 10.1128/AAC.01513-13. Epub 2013 Sep 16.

Carbapenemase-producing enterobacteriaceae in Spain in 2012

Jesús Oteo  1 , David Saez, Verónica Bautista, Sara Fernández-Romero, Juan Manuel Hernández-Molina, María Pérez-Vázquez, Belén Aracil, José Campos; Spanish Collaborating Group for the Antibiotic Resistance Surveillance Program
Affiliations

Carbapenemase-producing enterobacteriaceae in Spain in 2012

Jesús Oteo et al. Antimicrob Agents Chemother. 2013 Dec.

Abstract

We report the epidemiological impact of carbapenemase-producing Enterobacteriaceae (CPE) in Spain in 2012. Of the 237 carbapenemases detected, 163 were from the OXA-48 group, 60 were from VIM-1, 8 were from KPC-2, 5 were from IMP, and 1 was from NDM-1. Interhospital spread of carbapenemase-producing Klebsiella pneumoniae was due to a limited number of multilocus sequence types (MLST) and carbapenemase types, including ST15-VIM-1, ST11-OXA-48, ST405-OXA-48, ST101-KPC-2, and ST11-VIM-1. The number of CPE cases in Spain has increased sharply in recent years, due mainly to the emergence of OXA-48.

PubMed Disclaimer

Figures

Fig 1
Fig 1
Yearly evolution (2009–2012) of carbapenemase-producing Enterobacteriaceae in Spain and number of individual hospitals reporting cases to the national surveillance program of the Instituto de Salud Carlos III.
See this image and copyright information in PMC

References

    1. Cantón R, Akóva M, Carmeli Y, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Miriagou V, Naas T, Rossolini GM, Samuelsen Ø, Seifer H, Woodford N, Nordmann P, European Network on Carbapenemases 2012. Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin. Microb. Infect. 18:413–431 - PubMed
    1. Nordmann P, Dortet L, Poirel L. 2012. Carbapenem resistance in Enterobacteriaceae: here is the storm! Trends Mol. Med. 18:263–272 - PubMed
    1. Tzouvelekis LS, Markogiannakis A, Psichogiou M, Tasios PT, Daikos GL. 2012. Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions. Clin. Microb. Rev. 25:682–707 - PMC - PubMed
    1. Gómez-Gil MR, Paño-Pardo JR, Romero-Gómez MP, Gasior M, Lorenzo M, Quiles I, Mingorance J. 2010. Detection of KPC-2-producing Citrobacter freundii isolates in Spain. J. Antimicrob. Chemother. 65:2695–2697 - PubMed
    1. Miró E, Agüero J, Larrosa MN, Fernández A, Conejo MC, Bou G, González-López JJ, Lara N, Martínez-Martínez L, Oliver A, Aracil B, Oteo J, Pascual A, Rodríguez-Baño J, Zamorano L, Navarro F. 2013. Prevalence and molecular epidemiology of acquired AmpC β-lactamases and carbapenemases in Enterobacteriaceae isolates from 35 hospitals in Spain. Eur. J. Clin. Microbiol. Infect. Dis. 32:253–259 - PubMed

Publication types

MeSH terms

LinkOut - more resources