Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jul-Aug;104(7-8):415-9.
doi: 10.1701/1315.14588.

[Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates]

[Article in Italian]
Anna Guerra, Mario Carrano, Elisabetta Angrisani, Mario Vitale

[Diagnostic value of BRAFV600E and RET/PTC oncogenes in thyroid nodule aspirates]

[Article in Italian]
Anna Guerra et al. Recenti Prog Med. 2013 Jul-Aug.

Abstract

Fine-needle aspiration cytology (FNC) is the primary means to distinguish benign form malignant nodules. Aim of this study is to evaluate the diagnostic value of BRAF(V600E) and RET/PTC oncogenes in a large cohort of thyroid nodules with inconclusive FNC. We searched for BRAF(V600E) and RET/PTC in 299 thyroid nodule aspirates then removed by surgery. RET/PTC demonstrated a poor specificity. The search for BRAF(V600E) demonstrated to be useful in 25 cases, identifying a PTC in 2 false negative, 2 inadequate, 11 indeterminate and 10 suspicious FNC. Detection of BRAF(V600E) revealed to be a useful tool to refine inconclusive cytology.

PubMed Disclaimer

Publication types

MeSH terms