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Case Reports
. 2013 Nov 10;31(32):e439-42.
doi: 10.1200/JCO.2012.47.7521. Epub 2013 Sep 16.

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma

Nienke van Rooij  1 , Marit M van Buuren, Daisy Philips, Arno Velds, Mireille Toebes, Bianca Heemskerk, Laura J A van Dijk, Sam Behjati, Henk Hilkmann, Dris El Atmioui, Marja Nieuwland, Michael R Stratton, Ron M Kerkhoven, Can Kesmir, John B Haanen, Pia Kvistborg, Ton N Schumacher
Affiliations
Case Reports

Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma

Nienke van Rooij et al. J Clin Oncol. .
No abstract available

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Figures

Figure 1
Figure 1
Patient characteristics
Figure 2
Figure 2
Overview of screening procedure
Figure 3
Figure 3
Functional characterization of ATRS>L specific T cells
See this image and copyright information in PMC

Comment in

  • Tumor antigenicity revealed.
    Savage PA. Savage PA. Trends Immunol. 2014 Feb;35(2):47-8. doi: 10.1016/j.it.2014.01.001. Epub 2014 Jan 15. Trends Immunol. 2014. PMID: 24439426 Free PMC article.

References

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    1. Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455–2465. - PMC - PubMed
    1. Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443–2454. - PMC - PubMed
    1. Heemskerk B, Kvistborg P, Schumacher TN. The cancer antigenome. EMBO J. 2013;32:194–203. - PMC - PubMed
    1. Kvistborg P, Shu CJ, Heemskerk B, et al. TIL therapy broadens the tumor-reactive CD8+ T cell compartment in melanoma patients. Oncoimmu-nology. 2012;1:409–418. - PMC - PubMed

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