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. 2013 Jul;20(4):25-31.

MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above

Muhammad Fadli Embong  1 , Ruwaida Yaacob, Mohd Shafie Abdullah, Ahmad Helmy Abdul Karim, Anis Kausar Ghazali, Win Mar Salmah Jalaluddin
Affiliations

MR Volumetry of Hippocampus in Normal Adult Malay of Age 50 Years Old and Above

Muhammad Fadli Embong et al. Malays J Med Sci. 2013 Jul.

Abstract

Background: Hippocampal volume is affected by several psychiatric illnesses of old age, as well as by normal aging. It is important to have a normal data in a population to assist in diagnosis. The aim of this study is to determine hippocampal volume in normal Malay people aged 50 years old and older.

Methods: This was a cross-sectional study of the normal Malay population aged 50 to 77 years. We included 43 participants, representing 19 men and 24 women. Magnetic resonance imaging (MRI) was performed using a GE Signa Horizon LX 1.0 Tesla. Oblique coronal images of temporal lobes were obtained and hippocampal volumetry was done manually and normalised with intracranial volume.

Results: Mean right and left hippocampal volumes (HCVs) were 3.43 cm³ (SD 0.32) and 3.26 cm³ (SD 0.34), with a significant difference between them (P < 0.001). Total mean HCVs exhibited no significant difference between men and women (P = 0.234). The means of the normalised right and left HCVs were 3.42 cm³ (SD 0.31) and 3.26 cm³ (SD 0.32).

Conclusion: The mean right and left hippocampal volumes were significantly different in this study. Men had slightly larger mean HCVs but the difference was not statistically significant. It was found that normalisation further reduces the mean volume difference between the genders.

Keywords: 50 and over; Malay; aged; hippocampus; magnetic resonance imaging; normal value.

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Figures

Figure 1:
Figure 1:
Representative images in coronal plane of T1WI (TE = 11 msec, TR = 440 msec) of a 63 years old male subject showing the manual tracing of left hippocampus. (a) No clear boundary identified as alvelus is not visualised, therefore the head is separated from the overlying amygdala by drawing an arbitrary line below the uncal recess; (b) The alveus is included in the mesurement; (c) The first slice of the body is identified when choroidal fissure is visualised; (d) First slice of the tail is identified when the crus of fornix is in profile.
See this image and copyright information in PMC

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